{"id":73,"date":"2025-12-07T20:27:33","date_gmt":"2025-12-07T19:27:33","guid":{"rendered":"https:\/\/j-pet.pl\/?page_id=73"},"modified":"2026-01-12T14:15:08","modified_gmt":"2026-01-12T13:15:08","slug":"applications-theranostics","status":"publish","type":"page","link":"https:\/\/j-pet.pl\/?page_id=73","title":{"rendered":"APPLICATIONS &amp; THERANOSTICS"},"content":{"rendered":"<h2 class=\"wp-block-heading\" id=\"jpet-enables-and-enhances-applications-across\">J-PET enables and enhances applications across:<\/h2>\n\n\n<ul class=\"wp-block-list\" style=\"\">\n<li>Oncology &mdash; staging, recurrence, tumor metabolism<\/li>\n\n\n\n<li>Neurology &mdash; cognitive disorders, Alzheimer&rsquo;s research<\/li>\n\n\n\n<li>Cardiology &mdash; viability, perfusion, inflammatory disease<\/li>\n\n\n\n<li>Pediatric Imaging &mdash; low-dose protocols<\/li>\n\n\n\n<li>Targeted Radioligand Therapy (Theranostics)<\/li>\n\n\n\n<li>Proton Therapy Monitoring<\/li>\n\n\n\n<li>Dual-Tracer Imaging<\/li>\n<\/ul>\n\n\n\n<p>Theranostics is rapidly transforming cancer treatment\u2014and J-PET is engineered to unlock imaging capabilities required for expanding alpha- and beta-radiopharmaceutical therapies.<\/p>\n\n\n\n<p>The demonstration of the potential of J-PET technology for theranostics application was demonstrated in the Medical University of Warsaw. Fig. 1 shows the course of diagnosis and treatment of a patient with secondary recurrent glioblastoma with the application of the portable modular J-PET scanner.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"552\" src=\"https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-13-1024x552.png\" alt=\"\" class=\"wp-image-150\" srcset=\"https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-13-1024x552.png 1024w, https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-13-300x162.png 300w, https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-13-768x414.png 768w, https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-13.png 1387w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><em><strong>Fig. 1. Course of diagnosis and treatment of a patient with secondary recurrent glioblastoma<\/strong>. <br><strong>(A)<\/strong> The solid black curve indicates the decrease in the activity of the\u00a0 <sup>68<\/sup>Ga radionuclide after intravenous injection of a 178-MBq activity of the [<sup>68<\/sup>Ga]Ga-PSMA-11 radiopharmaceutical followed 131 min later by intratumoral administration of 8 MBq of [<sup>68<\/sup>Ga]Ga-DOTA- SP (black dashed curve) together with 20 MBq of [<sup>225<\/sup>Ac]Ac-DOTAGA-SP (red curve). After the first and the second administration of pharmaceuticals, the patient was imaged with the Siemens PET\/CT Biograph 64 TruePoint and then with a modular J-PET for the time indicated in the graph in yellow and turquoise, respectively. <br><strong>(B)<\/strong> The T2-weighed MRI coronal image of the head (Magnetom 3T, Siemens Healthcare) showing the tumor and the position of the cat-cath system (visible on the upper left part of the head) for the administration of a radiopharmaceutical for the local treatment of glioblastoma. <\/em><em><br>(C\u00a0to\u00a0F) Photographs illustrating the course of patient imaging with the modular J-PET scanner. <br><strong>(C) <\/strong>Modular J-PET scanner placed behind the PET\/CT Biograph 64. <br><strong>(D) <\/strong>View of the patient\u2019s bed from the inside of the J-PET tomograph. <br><strong>(E) <\/strong>The patient was moved on the table so that the torso and legs were in the Biograph PET\/CT and the head in the J-PET scanner. In this view, only the patient\u2019s feet are visible on the edge of the Biograph PET\/CT. (F) Photograph of the patient with the head inside of the J-PET scanner during imaging after intravenous administration of the [<sup>68 <\/sup>Ga]Ga-PSMA-11 radiopharmaceutical. <\/em><br><em><strong>The figures and caption are taken from the article published in Science Advances where more details about the medical protocol are available. <\/strong><\/em><br><em><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adp2840\">https:\/\/www.science.org\/doi\/10.1126\/sciadv.adp2840<\/a><\/em><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>As a result of this study the first ever positronium image was demonsrated as described in Science Adavances published in 2024, and also in the a review on positronium imaging featured in the November 2025 issue of IEEE Transactions on Radiation and Plasma Medical Sciences available via link: <a href=\"https:\/\/engage.ieee.org\/index.php\/email\/emailWebview?email=NzU2LUdQSC04OTkAAAGfOXYlpqLIr_vMv8SpUCbXDu9ksEmUy_iBk9F13jm86BPlnVKAAm_lDtAZTRYLnhCf97YKaoUHlG-h1EzCJ-AL3XrwL8ygGp9u0CE\">IEEE Master email<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"960\" height=\"720\" src=\"https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-14.png\" alt=\"\" class=\"wp-image-152\" srcset=\"https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-14.png 960w, https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-14-300x225.png 300w, https:\/\/j-pet.pl\/wp-content\/uploads\/2026\/01\/obraz-14-768x576.png 768w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p><em><strong>Fig. 2. Positronium imaging of a human brain.<\/strong> <br><strong>(A)<\/strong> Photograph of the patient in the modular J-PET tomograph. The patient diagnosed with brain glioma was intravenously and intratumorally administered with pharmaceuticals labeled with the&nbsp; <sup>68 <\/sup>Ga radionuclide, which emits positrons and prompt gamma rays (the course of imaging is illustrated in&nbsp;Fig. 1 above). The superimposed arrows represent photons from electron-positron annihilation (blue dashed arrow) and prompt gamma from the deexcitation of the&nbsp; <sup>68 <\/sup>Zn* radionuclide (red solid arrow). The plastic strips of the tomograph in which the gamma rays interacted have been highlighted in yellow. <br><strong>The figures and caption are taken from the article published in Science Advances, where more details are available. <\/strong><br><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adp2840\">https:\/\/www.science.org\/doi\/10.1126\/sciadv.adp2840<\/a><\/em><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>J-PET enables and enhances applications across: Theranostics is rapidly transforming cancer treatment\u2014and J-PET is engineered to unlock imaging capabilities required for expanding alpha- and beta-radiopharmaceutical therapies. The demonstration of the potential of J-PET technology for theranostics application was demonstrated in the Medical University of Warsaw. Fig. 1 shows the course of diagnosis and treatment of<\/p>\n<div class=\"more-link\">\n\t\t\t\t <a href=\"https:\/\/j-pet.pl\/?page_id=73\" class=\"link-btn theme-btn\"><span>Read More <\/span> <i class=\"fa fa-caret-right\"><\/i><\/a>\n\t\t\t<\/div>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-73","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/j-pet.pl\/index.php?rest_route=\/wp\/v2\/pages\/73","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/j-pet.pl\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/j-pet.pl\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/j-pet.pl\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/j-pet.pl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=73"}],"version-history":[{"count":6,"href":"https:\/\/j-pet.pl\/index.php?rest_route=\/wp\/v2\/pages\/73\/revisions"}],"predecessor-version":[{"id":162,"href":"https:\/\/j-pet.pl\/index.php?rest_route=\/wp\/v2\/pages\/73\/revisions\/162"}],"wp:attachment":[{"href":"https:\/\/j-pet.pl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=73"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}